The Topics gathered here address pressing issues in Environmental Sciences, Medical & Biological Ethics, urban design and food production, enlightened use of Technology for human wellbeing, as well as re-thinking the function and role of Knowledge and Rationality from Islamic perspectives. Muslim thinkers and professionals must enrich the boundaries of contemporary ‘Islamic’ discourse by creatively drawing nourishment from their profound ethico-spiritual heritage and authentic rational–epistemic roots. This journey may potentially contribute to the emergence of a genuine Islamic alternative which integrates cosmology, soul-science, human-oriented technologies, and sustainable knowledge applications promoting a truly universal science which recognizes the transcendent source of Life.